Paul Stirling is the leading run-scorer of the series with 112 runs at a strike-rate of 180.64.
Dwayne Bravo will return to the West Indies set-up with this game.
After six years, West Indies have got an opportunity to clean sweep an opposition.
Ireland should look to be more aggressive with the bat in this game.
Murtagh last played for Ireland in the Lord's Test back in July.
Balbirnie is not new to captaincy though.
Paul Stirling, who missed out on the game against Scotland due to a niggle could be a risky pick.
Foakes pulled off an unimaginable, which bamboozled Irish batsman Andrew Balbirnie and was back in the hut in no time.
The Ireland fans were thrilled with this victory and congratulated the team.
That fightback from Balbirnie, despite all the odds against him, was terrific to watch.