Both Steve Smith and Marnus Labuschagne got out in the single digits on their BBL return.
Sixers' previous match against Melbourne Stars was a rain-marred affair where Moises Henriques and Co cruised to a 21-run victory.
The Heat lost 7 wickets for 7 runs in a space of 16 balls.
Heat will be eager to break into the top half of the points table as they will be bolstered by the arrival of AB de Villiers in their squad.
Salt and Weatherald didn't even break a sweat in the 101-run chase.
James Pattinson's five-wicket haul tormented the Strikers in their previous meeting.
Khan slammed 28 off 27 balls and hit 2 fours and a six in his innings.
De Villiers' decision of hanging up his Proteas shirt in May 2018 came as a shock for entire cricketing fraternity.
For the first time, the Heat defeated the Strikers at The Gabba.
He is also looking forward to playing alongside Chris Lynn.