Injury concerns increase for England ahead of World Cup.
Eoin Morgan is averaging 98.66 across his last ten innings in the ODI format.
Malan and Foakes will also receive their first ODI caps.
Hales' name was earlier withdrawn from all the squads by ECB.
Only one Indian has managed to make the cut.
Malan felt he deserved more chances at least in the shortest format.
More than the Vikings, this match is crucial for the Titans.
Cape Town Blitz might continue with their winning momentum but Durban Heat can take a win even in the absence of key International stars.
Tshwane Spartans could edge out the Cape Town Blitz due to depth in both batting and bowling line-ups.
He was dropped after the first Test against India.