Can one of the Stormers and Gladiators defy the odds and make the semis?
In another game on Wednesday, Swift Gallopers beat Heat Stormers by 66 runs.
Desert Riders have won both their opening matches of the tournament.
The way the competition has panned out thus far, Riders look more than likely to book a place in the last four
Considering the red-hot form of Mohammad Hafeez, Riders will be eager to post their third victory of the tournament.
The likes of Kamran Akmal and Salman Butt did well on this day.
Luke Wright is expected to emerge as the talisman for Swift Gallopers.