The Royals scored 54 runs in their last three overs and that turned out to be a decisive factor.
In the Qualifier 1, Mohammad Amir's six-wicket haul blew away the Royals.
Dre-Russ' heroics has shown Chattogram Challengers the door of elimination.
The Royals will be looking for a better show with the bat in order to roll over the Challengers.
Shoaib Malik tried to pull off a single-handed effort with a 50-ball 80, but he didn't get much support from the others.
It's a chance for both sides to qualify for the Final.
For the Challengers to finish in the top two, the match between Dhaka Platoon and Khulna Tigers can't have a winner.
The Royals need a win to have any chance of playing the Qualifier 1.
Universe Boss Chris Gayle announced himself, smashing 22 runs off Afif Hossain's first over.
Chris Gayle has joined the Challengers and is set to be their part for the rest of the season.