Jonathan Wells, who hogged the attention by smashing a brilliant half-century in his previous match, will be eager to replicate his heroics.
Thunder's bowling unit, which was inefficient in their previous match, will be hoping to retaliate against Hobart Hurricanes.
Sixers' previous match against Melbourne Stars was a rain-marred affair where Moises Henriques and Co cruised to a 21-run victory.
The return of Zampa and Handscomb from the India tour will help Melbourne Stars to bolster their squad.
In the previous encounter at Docklands, both the teams ticked the 160-run mark on the scoreboard.
The successful duo of Daniel Sams and Chris Morris will be steering Thunder's bowling force.
Heat will be eager to break into the top half of the points table as they will be bolstered by the arrival of AB de Villiers in their squad.
Hobart Hurricanes have registered three wins out of ten in the competition and have amassed just six points.
Stirling grabbed the limelight in the first T20I by smashing 95 runs off just 47 balls.
Melbourne Stars have been in phenomenal form this season and are currently poised at the top of the table.