Leeward Islands are the favourites to win the final match and seal the title of Super50 Cup 2019.
Jonathan Foo is Guyana's highest run-scorer this season with 293 runs in seven innings.
Andre McCarthy will be beneficial due to his all-round abilities.
Both teams will be hoping for some individual performances to guide them to their second win of the tournament.
Darren Bravo has scored 269 runs in five outings with a best of 119*.
Devon Thomas scored 272 runs at an average of 68 in this tournament thus far.
Jamaica would like to carry on with their winning streak against Barbados.
Kavem Hodge amassed 197 runs in five innings and also claimed three wickets at an economy of 3.92.
Ashley Nurse claimed 12 wickets from 5 matches and scored 57 runs in 3 innings.
Veerasammy Permaul has claimed 8 wickets at an average of 17.5 from four games.